PD01-10 SMALL FIBER POLYNEUROPATHY: A NEXUS LINKING CO-OCCURRING PAIN SYNDROMES IN WOMEN WITH INTERSTITIAL CYSTITIS/BLADDER PAIN SYNDROME?

You have accessJournal of UrologyInfections/Inflammation/Cystic Disease the Genitourinary Tract: Interstitial Cystitis (PD01)1 Sep 2021PD01-10 SMALL FIBER POLYNEUROPATHY: A NEXUS LINKING CO-OCCURRING PAIN SYNDROMES IN WOMEN WITH INTERSTITIAL CYSTITIS/BLADDER SYNDROME? Raymond Xu, Tyler Overholt, Catherine A. Matthews, Robert Evans, Gopal Badlani, Christine Ahn, Trang Simon, and Stephen J. Walker XuRaymond Xu More articles by this author , OverholtTyler Overholt MatthewsCatherine Matthews EvansRobert Evans BadlaniGopal Badlani AhnChristine Ahn SimonTrang Simon WalkerStephen View All Author Informationhttps://doi.org/10.1097/JU.0000000000001965.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Patients with interstitial cystitis/bladder pain syndrome (IC/BPS) often one or more co-occurring chronic syndromes (e.g., pelvic (CPP), fibromyalgia (FM), and/or vulvodynia (VD)). The objective study was explore role small fiber polyneuropathy (SFPN) as a potential nexus between IC/BPS syndromes. METHODS: Fifty-one women undergoing therapeutic hydrodistention (HOD) provided skin biopsy from distal calf. Processed tissue stained protein gene product (PGP) 9.5, marker for intraepidermal nerve fibers (IENF), SFPN (+/-) status determined comparing linear IENF density (fibers/mm2; Figure 1) normative reference values. Co-occurring CPP, FM, VD) patient report. RESULTS: Approximately quarter (13/51; 25.49%) in cohort were SFPN+. Average age (years) SFPN+ patients 40.92 versus 48.73 without (SFPN-). Among patients, widespread 76.92% (10/13), 46.15% (6/13), 38.46% (5/13) (VD), respectively. SFPN- group, 42.10% (16/38), 36.84% (14/38), 15.79% (6/38) reported VD, respectively (Table 1). CONCLUSIONS: Contrary range values that show decreases age, were, on average, almost 8 years younger than their counterparts. higher prevalence pain, fibromyalgia, vulvodynia. There high concordance co-occurrence CPP (∼77%), suggesting possible etiological generalized descriptor. Further studies determine mechanisms which may contribute are warranted. Source Funding: 1R01DK124599-01 (Walker, PI) © 2021 American Urological Association Education Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e34-e35 Advertisement Copyright & Permissions© Inc.MetricsAuthor Information Expand Loading ...